Table 3. Number of patients randomized to each treatment arm using the fixed-reference adaptive randomization (FAR) compared to the moving-reference adaptive randomization (MAR). The most efficacious dose is in boldface.
| Response rate |
FAR |
MAR |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Sc. | Arm 1 | Arm 2 | Arm 3 | Arm 1 | Arm 2 | Arm 3 | Arm 1 | Arm 2 | Arm 3 |
| 1 | 0.1 | 0.2 | 0.3 | 27.7 | 31.8 | 40.6 | 12.5 | 29.0 | 58.5 |
| 2 | 0.2 | 0.1 | 0.3 | 40.5 | 17.2 | 42.4 | 27.3 | 13.0 | 59.7 |
| 3 | 0.3 | 0.1 | 0.2 | 61.1 | 13.7 | 25.2 | 58.4 | 13.1 | 28.5 |
| 4 | 0.1 | 0.3 | 0.6 | 23.3 | 33.8 | 42.9 | 5.5 | 13.3 | 81.3 |
| 5 | 0.3 | 0.6 | 0.1 | 34.4 | 54.6 | 11.0 | 13.9 | 80.5 | 5.5 |
| 6 | 0.6 | 0.3 | 0.1 | 82.2 | 12.5 | 5.3 | 81.8 | 12.8 | 5.3 |
| 7 | 0.01 | 0.4 | 0.6 | 21.0 | 38.7 | 40.3 | 3.7 | 20.6 | 75.7 |
| 8 | 0.01 | 0.01 | 0.5 | 25.8 | 25.1 | 49.1 | 5.3 | 5.3 | 89.4 |