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. Author manuscript; available in PMC: 2012 Feb 26.
Published in final edited form as: Ann Appl Stat. 2011 Jan 1;5(2A):924–942. doi: 10.1214/10-AOAS433

Table 4. Sensitivity analysis of the proposed Bayesian phase I/II drug-combination design under different prior specifications.

Selection percentage
Number of treated patients
Sc. α,β ~ Ga(0.1, 0.1) α,β ~ Ga(0.05,0.05) α,β ~ Ga(0.1, 0.1) α,β ~ Ga(0.05,0.05)
1 2.0 21.0 25.4 2.0 19.9 27.1 7.8 15.7 20.2 7.7 15.7 20.8
0.1 8.2 41.8 0 9.0 40.2 7.4 9.6 18.3 7.1 9.6 18.1
2 5.4 46.5 2.9 4.9 45.9 3.7 10.6 21.6 9.6 10.5 21.4 9.4
0.4 21.0 20.3 0.2 22.9 17.9 8.8 14.4 13.0 8.8 14.9 12.5
3 2.0 6.3 69.6 0.9 6.1 70.2 7.2 10.1 36.3 6.8 9.8 36.4
0.1 1.2 19.4 0 1.4 19.9 7.1 6.5 12.1 7.0 6.6 12.5
4 16.9 24.7 0.2 15.6 24.6 0.3 15.2 16.4 4.0 15.1 16.0 4.3
4.8 44.2 2.8 4.1 45.1 3.0 13.1 20.6 6.8 13.2 20.4 6.2