Table 4. Sensitivity analysis of the proposed Bayesian phase I/II drug-combination design under different prior specifications.
Selection percentage |
Number of treated patients |
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Sc. | α,β ~ Ga(0.1, 0.1) | α,β ~ Ga(0.05,0.05) | α,β ~ Ga(0.1, 0.1) | α,β ~ Ga(0.05,0.05) | ||||||||
1 | 2.0 | 21.0 | 25.4 | 2.0 | 19.9 | 27.1 | 7.8 | 15.7 | 20.2 | 7.7 | 15.7 | 20.8 |
0.1 | 8.2 | 41.8 | 0 | 9.0 | 40.2 | 7.4 | 9.6 | 18.3 | 7.1 | 9.6 | 18.1 | |
2 | 5.4 | 46.5 | 2.9 | 4.9 | 45.9 | 3.7 | 10.6 | 21.6 | 9.6 | 10.5 | 21.4 | 9.4 |
0.4 | 21.0 | 20.3 | 0.2 | 22.9 | 17.9 | 8.8 | 14.4 | 13.0 | 8.8 | 14.9 | 12.5 | |
3 | 2.0 | 6.3 | 69.6 | 0.9 | 6.1 | 70.2 | 7.2 | 10.1 | 36.3 | 6.8 | 9.8 | 36.4 |
0.1 | 1.2 | 19.4 | 0 | 1.4 | 19.9 | 7.1 | 6.5 | 12.1 | 7.0 | 6.6 | 12.5 | |
4 | 16.9 | 24.7 | 0.2 | 15.6 | 24.6 | 0.3 | 15.2 | 16.4 | 4.0 | 15.1 | 16.0 | 4.3 |
4.8 | 44.2 | 2.8 | 4.1 | 45.1 | 3.0 | 13.1 | 20.6 | 6.8 | 13.2 | 20.4 | 6.2 |