Table 5. Number of patients allocated to the target dose combination and the trial duration (shown as subscripts), with different group sizes m under scenarios 1–5.
| Hazard (accrual rate=2/month) |
Hazard (accrual rate=8/month) |
|||||||
|---|---|---|---|---|---|---|---|---|
| m | Increase | Constant | Decrease | Hump | Increase | Constant | Decrease | Hump |
| Scenario 1 | ||||||||
| 1 | 18.4157.8 | 18.1150.3 | 17.7139.5 | 17.8159.9 | 18.2149.4 | 17.5143.0 | 17.8131.5 | 17.4152.2 |
| 3 | 18.069.8 | 18.069.2 | 17.568.7 | 17.969.4 | 17.261.6 | 17.760.9 | 17.960.7 | 17.561.5 |
| 6 | 17.742.4 | 17.442.4 | 16.942.4 | 17.342.2 | 17.633.0 | 17.132.8 | 17.332.8 | 16.732.9 |
| 12 | 16.542.2 | 16.842.2 | 16.142.1 | 16.542.0 | 16.618.8 | 16.618.7 | 16.918.8 | 16.918.7 |
| 20 | 15.842.1 | 16.042.1 | 15.842.1 | 15.742.1 | 15.613.8 | 16.313.8 | 16.113.8 | 15.413.7 |
| 30 | 15.042.1 | 15.442.1 | 15.042.0 | 15.242.0 | 15.012.8 | 15.112.8 | 15.312.8 | 14.312.8 |
| Scenario 2 | ||||||||
| 1 | 21.0160.2 | 20.7153.7 | 22.5145.3 | 21.9162.3 | 21.3151.9 | 21.7146.9 | 22.0135.8 | 21.2154.5 |
| 3 | 20.869.5 | 21.669.4 | 21.968.6 | 21.569.2 | 21.361.3 | 21.261.2 | 21.560.8 | 20.961.1 |
| 6 | 20.742.3 | 21.142.1 | 21.742.2 | 20.942.1 | 20.732.8 | 21.632.7 | 21.832.6 | 20.932.6 |
| 12 | 20.542.0 | 20.842.0 | 21.242.1 | 20.941.9 | 20.518.6 | 20.818.6 | 21.018.7 | 20.618.7 |
| 20 | 20.242.0 | 19.142.1 | 20.242.0 | 20.842.1 | 20.013.7 | 19.313.7 | 20.113.8 | 19.613.7 |
| 30 | 19.142.2 | 19.642.1 | 19.641.9 | 19.742.1 | 18.612.8 | 19.612.8 | 18.512.8 | 19.312.8 |
| Scenario 3 | ||||||||
| 1 | 32.2161.2 | 32.0154.6 | 31.7144.7 | 31.1163.6 | 31.9153.8 | 32.0147.1 | 32.1136.6 | 32.3156.5 |
| 3 | 31.570.1 | 31.869.7 | 31.469.2 | 31.569.9 | 31.061.8 | 31.361.7 | 32.061.2 | 31.561.9 |
| 6 | 32.442.4 | 31.042.4 | 32.242.3 | 30.942.4 | 31.233.0 | 31.033.0 | 32.432.9 | 31.532.9 |
| 12 | 30.842.2 | 31.042.2 | 30.342.1 | 30.342.3 | 30.418.8 | 30.618.8 | 31.418.8 | 31.918.8 |
| 20 | 29.542.3 | 30.442.1 | 29.642.2 | 30.142.1 | 28.713.8 | 28.213.8 | 28.213.8 | 29.013.8 |
| 30 | 29.442.2 | 29.142.2 | 28.942.2 | 29.142.2 | 26.412.8 | 26.712.8 | 26.412.8 | 26.512.8 |
| Scenario 4 | ||||||||
| 1 | 23.0158.4 | 23.7151.5 | 22.8139.4 | 22.4159.5 | 23.5150.4 | 22.7143.8 | 22.3131.3 | 22.6151.9 |
| 3 | 22.769.1 | 22.368.9 | 22.668.7 | 22.469.1 | 22.361.0 | 22.860.9 | 21.959.8 | 21.061.2 |
| 6 | 21.842.4 | 21.742.2 | 22.542.3 | 21.342.3 | 22.232.6 | 21.932.8 | 22.432.9 | 21.532.7 |
| 12 | 21.242.1 | 21.341.9 | 20.742.1 | 21.041.8 | 20.418.6 | 22.018.7 | 21.918.7 | 21.218.7 |
| 20 | 20.242.1 | 20.342.1 | 19.842.0 | 20.142.0 | 20.013.7 | 20.113.7 | 19.913.7 | 20.313.8 |
| 30 | 19.342.2 | 19.342.1 | 18.642.1 | 19.442.2 | 19.512.8 | 19.212.7 | 20.212.8 | 18.912.8 |
| Scenario 5 | ||||||||
| 1 | 20.4159.7 | 21.3152.1 | 19.8141.1 | 20.3161.6 | 20.5152.4 | 20.5144.7 | 21.1133.4 | 20.9154.1 |
| 3 | 20.070.1 | 20.669.9 | 20.469.1 | 20.169.9 | 20.461.8 | 20.061.5 | 20.361.1 | 19.661.9 |
| 6 | 19.942.5 | 19.642.5 | 19.942.5 | 20.042.5 | 19.533.0 | 19.632.9 | 20.033.0 | 20.533.0 |
| 12 | 19.242.2 | 19.342.3 | 19.742.2 | 20.042.3 | 19.118.8 | 19.218.8 | 18.718.8 | 19.618.8 |
| 20 | 19.542.3 | 19.542.3 | 18.842.2 | 18.842.3 | 18.313.8 | 18.813.8 | 18.613.8 | 18.813.8 |
| 30 | 18.542.3 | 18.142.2 | 19.142.2 | 18.442.3 | 17.212.8 | 17.612.8 | 17.712.8 | 17.712.8 |