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. Author manuscript; available in PMC: 2012 Feb 26.
Published in final edited form as: Cancer Cell. 2010 Jul 13;18(1):39–51. doi: 10.1016/j.ccr.2010.05.023

Figure 1. Tumor Cells with Coexistent RAS or RAF Mutations Are Resistant to AKT Inhibition.

Figure 1

(A) Cell growth was assessed by using the CellTiter-Glo luminescent cell viability assay after 3 days of treatment with AKTi (0–10 µM). The results are expressed as half-maximal growth inhibitory concentration (IC50) of AKTi.

(B) Cells were treated with 1 µM AKTi, and the cell lysates were immunoblotted with the indicated antibodies. See also Figure S1.