Figure 8. Barium-sensitive inwardly rectifying potassium conductance does not control action potential generation in murine corticotrophs.

A, representative voltage-clamp recording of a metabolically intact corticotroph in the presence of elevated (20 mm) extracellular potassium and step hyperpolarised from −50 mV to −100 mV before (Cont) and after addition of 100 μm BaCl₂ to the bath. B, current-clamp recording of corticotroph in physiological extracellular solution exposed to 100 μm BaCl₂ (horizontal open bar). Note lack of Ba²⁺ on firing. Grey shading indicates membrane potential between −50 and +10 mV.