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. 2011 Oct 24;589(Pt 24):6093–6104. doi: 10.1113/jphysiol.2011.220863

Figure 7. Computer-generated models suggest distinction between monomeric KCNQ1, endogenous IKs and IKs with KCNE1 overexpression.

Figure 7

A, model-derived current traces for KCNQ1 monomeric channels, a linear combination (∼80%–20%) of KCNQ1 and KCNQ1+KCNE1 channels (simulating endogenous hESC-CMs IKs voltage dependence), and KCNQ1+KCNE1 channels alone. B, activation curves taken from maximal open probability for test voltages from −40 to +50 mV show that a population of channels composed of KCNQ1 homomers mixed with KCNQ1/KCNE1 heteromultimers would predict a substantially flatter activation curve.