Table 4.

Evidence that the association between rs6983267 and thyroid cancer risk is best explained by a recessive model

Test	UK only		Meta analysis of UK and Polish studies
	OR (95% CI)	p Value	OR (95% CI)	p Value
GG vs (GT + TT)	1.266 (1.071 to 1.494)	0.004	1.250 (1.089 to 1.435)	7.64×10−4
GG vs GT	1.262 (1.055 to 1.509)	0.009	1.215 (1.051 to 1.404)	0.004
GT vs TT	1.010 (0.827 to 1.236)	0.960	1.087 (0.933 to 1.266)	0.142

Note that the risk allele homozygotes (GG) have significantly higher frequency compared with other genotypes combined (GT + TT) and with heterozygotes (GT). This is also the case for the GG versus TT test which is not shown. However, there is no evidence that heterozygotes are over-represented in cases (GT vs TT).