Table 1.
Patient and Transplant demographics
Study group n=46 |
|
---|---|
Sex (male/female) | 27/19 |
| |
Median age (range) at HCT | 13.9 (6–23) |
Median age (range) at vaccination | 14.7 (9.6–25.4) |
| |
Diagnosis | |
Malignancy/bone marrow failure | 40 |
Acute Leukemia | 32 |
MDS/aplastic anemia | 5 (3/2) |
CML/myeloproliferative disorder | 2 (1/1) |
Ewing’ sarcoma | 1 |
Non-malignant disease | 6 |
Hemoglobinopathy | 4 |
Combined immunodeficiency disease | 1 |
Hereditary Lymphohistiocytosis | 1 |
| |
Median time (range) from HCT to vaccine | 2.34 (0.6–5.2) years |
| |
Donor | |
HLA-identical sibling | 17 (37%) |
HLA-Mismatched related | 6 (13%) |
Unrelated | 23 (50%) |
| |
HCT type | |
T cell depleted | 26 (57%) |
T cell depleted HLA-identical sibling | 4 |
T cell depleted HLA-mismatched related | 6 |
T cell depleted Unrelated | 16 |
T-replete | 20 (43%) |
Unmodified HLA-identical sibling | 13 |
Unmodified Unrelated | 2 |
Unmodified double cord blood | 5 |