Table 1.
Patient and Transplant demographics
| Study group n=46 |
|
|---|---|
| Sex (male/female) | 27/19 |
|
| |
| Median age (range) at HCT | 13.9 (6–23) |
| Median age (range) at vaccination | 14.7 (9.6–25.4) |
|
| |
| Diagnosis | |
| Malignancy/bone marrow failure | 40 |
| Acute Leukemia | 32 |
| MDS/aplastic anemia | 5 (3/2) |
| CML/myeloproliferative disorder | 2 (1/1) |
| Ewing’ sarcoma | 1 |
| Non-malignant disease | 6 |
| Hemoglobinopathy | 4 |
| Combined immunodeficiency disease | 1 |
| Hereditary Lymphohistiocytosis | 1 |
|
| |
| Median time (range) from HCT to vaccine | 2.34 (0.6–5.2) years |
|
| |
| Donor | |
| HLA-identical sibling | 17 (37%) |
| HLA-Mismatched related | 6 (13%) |
| Unrelated | 23 (50%) |
|
| |
| HCT type | |
| T cell depleted | 26 (57%) |
| T cell depleted HLA-identical sibling | 4 |
| T cell depleted HLA-mismatched related | 6 |
| T cell depleted Unrelated | 16 |
| T-replete | 20 (43%) |
| Unmodified HLA-identical sibling | 13 |
| Unmodified Unrelated | 2 |
| Unmodified double cord blood | 5 |