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Reduction of titers of RSV in the lungs of cotton rats vaccinated with measles-vectored RSV F after challenge. Naive cotton rats were immunized with 105 PFU of sF1 or sF3 on day 0 and 28. Cotton rats were then challenged with 106 PFU of RSV A2 on day 56. Lungs were harvested on day 60 and RSV titers were determined in the lung homogenates by standard plaque assay. Each experimental group represents 5 individual animals except in UVinactivated sF3 group (n=3).
