Table 6.
Summary of Preclinical Studies Supporting a Role of mGluRs in Pain
| Receptor Subtype | Pharmacological Tool | Effect | References |
|---|---|---|---|
| Group I | |||
| mGluR1 | A841720 (antagonist) | ↓ CFA-induced pain in rats | El-Kouhen et al. 2006;Zheng et al. 2005 |
| ↓ Mechanical allodynia in rats | |||
| A841720 | ↓ Post-operative pain in rats | Zhu et al. 2008 | |
| A794282 | |||
| A794278 | |||
| A850002 (antagonists) | |||
| CPCCOEt (antagonist) | ↓ Formalin- induced pain in mice | Bhave et al. 2001;Han and Neugebauer 2005 | |
| ↓ Thermal hyperalgesia in mice | |||
| ↓ Noxious stimulation- induced pain in rats | |||
| AIDA | ↓ Formalin- induced pain in mice | Lee et al. 2007;Varty et al. 2005;Zhang et al. 2002 | |
| LY456236 | ↓ Thermal hyperalgesia in mice and rats | ||
| LY36738 (antagonists) | ↓ Mechanical allodynia in rats | ||
| mGluR5 | SIB1757 (antagonist) | ↓ Thermal hyperalgesia in rats | Dogrul et al. 2000 |
| MPEP & MTEP (antagonists) | ↓ Formalin- induced pain in mice | Bhave et al. 2001;Vartyet al. 2005;Zhu et al. 2004;Lee et al. 2007;Walkeret al. 2001 | |
| ↓ Post-operative pain in rats | |||
| ↓Thermal hyperalgesia in mice | |||
| ↓ Noxious stimulation- induced pain in rats | |||
| ↓ Carrageenan- induced pain in mice | |||
| ↓ CFA- induced pain in rats | |||
| ↓ Touch-evoked allodynia in mice | |||
| ↓ Mechanical allodynia in mice | |||
| Group II | |||
| LY354740 | ↓ Carrageenan- induced pain in rats | Simmons et al. 2002;Jones et al. 2005 | |
| LY379268 | ↓ CFA-induced pain in rats | ||
| mGluR2/3 | LY389795 (agonists) | ↓ Formalin-induced pain in rats | |
| ↓ Mechanical allodynia in rats | |||
| ↓ Thermal hyperalgesia in rats | |||
| APDC (agonist) | ↓ Thermal-induced pain in rats | Neugebauer and Carlton 2002;Yang and Gereau 2003 | |
| ↓ Formalin-induced pain in rats | |||
| ↓ Carrageenan- induced pain in mice | |||
| ↓ CFA- induced pain in rats | |||
| ↓ Thermal hyperalgesia in rats | |||
| Group III | |||
| mGluR4/7/8 | l-AP4 (agonist) | ↓ Mechanical allodynia in rats | Chen and Pan 2005 |
| ACPT-I (agonist) | ↓ Carrageenan-induced pain in rats | Goudet et al. 2008 | |
| ↓ Vincristine-induced pain in rats | |||
| mGluR4 | PHCCC (PAM) | ↓ Carrageenan-induced pain in rats | Goudet et al. 2008 |
| ↓ Vincristine-induced pain in rats | |||
| mGluR7 | AMN082 (agonist) | ↓ Carrageenan-induced pain in rats | Palazzo et al. 2008 |
| (S)-3,4-DCPG (agonist) | ↓ Carrageenan-induced pain in rats | Palazzo et al. 2008 | |
| ↓ Vincristine-induced pain in rats | |||
Abbreviations and symbols: ↓, decreased; CFA, complete Freund's adjuvant; NAM, negative allosteric modulator; PAM, positive allosteric modulator.