Table 2. Conservation of autophosphorylation sites in eEF2K.
+, conserved; (+), local conservation weak, but residue probably conserved; −, local conservation strong, site not conserved; single letter code is used to indicate conservative replacements.
| Species | Ser61 | Ser66 | Ser78 | Thr348 | Thr353 | Ser366 | Ser445 | Ser474 | Ser491 |
|---|---|---|---|---|---|---|---|---|---|
| Human | + | + | + | + | + | + | + | + | + |
| Mouse | + | T | + | + | + | + | + | + | − |
| Rat | − | T | + | + | + | + | + | + | − |
| Cow | + | + | + | + | + | + | + | + | + |
| Lizard (Anolis carolinensis) | + | + | + | + | + | + | + | + | − |
| Zebra finch | − | T | + | + | + | + | + | + | + |
| Zebrafish | − | T | + | + | + | + | + | + | + |
| Acorn worm (Saccoglossus kowalevskii) | − | − | − | + | S | − | T | − | − |
| Strongylocentrotus purpuratus | − | − | − | + | + | − | − | − | − |
| Aplysia californica | − | − | − | + | − | − | − | + | − |
| Ascaris suum | − | − | − | (+) | S | − | − | (+) | − |
| Caenorhabditis elegans | − | − | − | (+) | − | − | − | (+) | − |
| Loa loa | − | − | − | S | S | − | − | − | − |
| Caenorhabditis briggsae | − | − | − | (+) | − | − | − | (+) | − |