Table 1. Summary of previously reported experiments of MRT with animals.

Author; journal; year	Tumor cell line	Implantation site	Irradiation geometry	Beam width (µm)	Center-to-center distance (µm)	Peak dose (Gy)	Valley dose (Gy)	Evaluation criteria
Laissue et al.; Int. J. Cancer; 1998	9L gliosarcoma	Brain	Co-planar	25	100	625		Survival rate
			Orthogonal	25	100	312.5		Tumor size
			Orthogonal	25	100	625		Normal brain damage
Dilmanian et al.; Neuro-Oncology; 2002	9L gliosarcoma	Brain	Co-planar	27	50	150–300	20–40	Survival rate
			Co-planar	27	75	250–500	17–33	MRI (tumor size, normal brain damage)
			Co-planar	27	100	500	19
Dilmanian et al.; Radiat. Res.; 2003	Murine EMT-6 mammary carcinoma	Hind leg	Co-planar	90	300	800–1900	16–38	Tumor size
			Cross-planar	90	300	410–650	16–26	Normal tissue toxicity
Smilowitz et al.; J. Neuro-oncology; 2006	9L gliosarcoma	Brain	Co-planar	25	211	625		Survival rate
Miura et al.; Br. J. Radiol.; 2006	Human squamaous cell carcinoma	Hind leg	Orthogonal	35	200	442		Tumor size
			Orthogonal	35	200	625		Normal tissue toxicity
			Orthogonal	35	200	884
			Orthogonal	70	200	442
Regnard et al.; Phys. Med. Biol.; 2008	9L gliosarcoma	Brain	Co-planar	25	100	625	36	Survival rate
			Co-planar	25	200	625	12.1	Clinical sign
								Body weight pattern
Serduc et al.; Phys. Med. Biol.; 2008	9L gliosarcoma	Brain	Orthogonal	25	211	500	24	Survival rate
								MRI (blood volume, vessel size)
Schültke; Eur. J. Radiol.; 2008	F98 glioma	Brain	Orthogonal	25	211	350		Survival rate
	C6 glioma
Serduc et al.; Phys. Med. Biol.; 2009	9L gliosarcoma	Brain	Orthogonal	25	211	860	36	Survival rate
			Orthogonal	50	211	480	36
			Orthogonal	75	211	320	36
Serduc et al.; J. Synchrotron Rad.; 2009	9L gliosarcoma	Brain	Three fractions through three orthogonal ports at 24 h intervals	50	211	400 (two directions)	15 per exposure	Survival rate
						360 (one direction)		Memory function
This work	Human U251 glioma	Hind leg	Co-planar	100	500	124	4.8	Tumor size
			Cross-planar	100	500	124	9.6
			Cross-planar	20	100	111	8.2