Skip to main content
. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: J Surg Res. 2011 Oct 8;173(1):e1–e10. doi: 10.1016/j.jss.2011.09.021

Figure 2.

Figure 2

Proliferation of male and female rat vascular smooth muscle cells (VSMC) exposed to inhibitors to ERα, ERβ, or ERαβ. No reversal of NO-mediated inhibition of VSMC proliferation was observed after treatment with the A) ERα inhibitor, MPP or B) the ERβ inhibitor, THC. C) The ERαβ inhibitor ICI resulted in partial reversal of NO-mediated inhibition of proliferation in female VSMC at all concentrations but only male VSMC at the highest concentration (*P < 0.05 compared to same sex NO). No reversal of NO-mediated inhibition of VSMC proliferation was observed after use of the D) androgen receptor inhibitor, flutamide, or E) the aromatase inhibitor, formestane. NO = DETA/NO 500 μM. Data are representative of at least 3 separate experiments. n=3/treatment group.