Table 1.

Classification criteria for autoimmune diseases in humans. Comparison between ADs and autoinflammatory diseases.

			Diseases
			SLE	RA	SS	AS	PsA	IBD
Direct proof	Antibody-mediated	Circulating ABs which alter the function	+	+	+
		Localized ABs	+	+	+
		IC located at lesion	+	+	+	+
		Passive transference	+		+
	Cells-mediated	In vitro T-cell proliferation in respond to autoantigen	+
		In vitro T-cell transference to immune-deficient mice	+
		In vitro T-cell cytotoxicity against target organ cells	+	+	+
Indirect proof		Disease reproduction by experimental immunization	+	+	+	+	+	+
		Disease reproduction by idiotypes	+	+				+
		Spontaneous animal models	+	+	+	+	+	+
		Animal models produced by immune system deregulation	+	+	+	+	+	+
Circumstantial evidence		Auto-ABs	+	+	+
		Other AD association	+	+	+		+	+
		HLA association	+	+	+	+	+	+
		Lymphocytic infiltration in target organ	+	+	+	+	+
		Good response to immune suppression	+	+	+	+	+	+

AS: ankylosing spondylitis, PsA: psoriatic arthritis, IBD: inflammatory bowel disease, SS: Sjögren's syndrome, RA: rheumatoid arthritis, SLE: systemic lupus erythematosus, AD: autoimmune disease, ABs: antibodies, and IC: immune complexes.