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. 2011 Jun 20;109(8):2736–2741. doi: 10.1073/pnas.1018859108

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Fig. 2. — HOXB7 promotes acquired TAM resistance. (A) Immunoblot analysis of Phospho-EGFR (Y1068), EGFR, Phospho-MAPK, MAPK, Phospho-ERα (S118), ERα, and HOXB7 expression in MCF-7 cells treated long term with vehicle or 0.1 μM TAM (TMR1) or 1 μM TAM (TMR2). (B) Immunoblot analysis of EGFR, Phospho-MAPK, MAPK, and HOXB7 expression in MCF-7-TMR cells and BT474 transfected with either scrambled sequence siRNA or HOXB7-specific siRNA. (C) Soft agar colony formation in BT474 cells and MCF-7-TMR cells transfected with either scrambled sequence siRNA or HOXB7-specific siRNA treated with vehicle or 1 μM TAM. (D) Soft agar colony formation by BT474 cells and MCF-7-TMR cells treated with 1 μM gefitinib and 1 μM TAM.