Fig. 1.

The key miRNA changes along the cancer progression from normal breast to DCIS and then to IDC. The three miRNAs with bold typeface were those with expression reversal, as indicated by the colors (red, up-regulation; green, down-regulation). Sixty-six miRNAs were deregulated in the first transition, normal breast to DCIS (only the most significant miRNAs are listed). Nine miRNAs were deregulated in the invasion transition, DCIS to IDC, and they are all listed. We defined this second signature as the invasiveness microsignature. None of the miRNAs involved in the invasion transition was differentially regulated, with the same trend in the first carcinoma transition.