Fig. 2.

Water-deprivation test in female WT (n = 10), LXRα^−/− (n = 10), and LXRβ^−/− (n = 10) mice. (A) The 24-h urine volume was significantly decreased in all three strains studied after dehydration (WD), with a parallel increase in serum osmolality (B). (C) Urine osmolality is increased in dehydrated as compared with nondehydrated LXRβ^−/− and WT mice. (D) The percentage of body weight loss during water deprivation is significantly higher in LXRβ^−/− mice than in dehydrated WT mice. (E) Food intake was not affected during water deprivation. Data are presented as mean ± SEM; *P < 0.05; **P < 0.001 versus WT.