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Tissue-infiltrating T cells display an activated phenotype. (A and B) Representative histograms of CD3+CD4+ (Upper) or CD3+CD8+ (Lower) T cells isolated from a single CTX-treated patient with both normal (blue) and tumor (red) tissue. Expression of activation markers CD69 (Left), HLA-DR (Center Left), CD45RA (Center Right), and CD27 (Right) are shown in A, and expression of chemokine receptors CCR4 (Left), CCR5 (Center Left), CCR7 (Center Right) and CXCR3 (Right) are shown in B.
