Table 1.
Identification of multiple transcriptional factors regulated by tobacco smoke in A549 cells using protein-DNA arrays I, II and III
| TF Name | Regulation by Smoke | Ratio |
|---|---|---|
| GATA | Increase | * |
| GRE | Increase | * |
| TR(DR4) | Increase | 7.2 |
| NF-κB | Increase | * |
| VDR(DR3) | Increase | 12.1 |
| RXR(DR1) | Increase | 6.9 |
| PAX5 | Increase | 8.8 |
| Stat 4 | Increase | 8.4 |
| c-Myb | Increase | 12.2 |
| NF1 | Increase | 4.7 |
| Smad 3/4 | Increase | 7.2 |
| TFIID | Increase | * |
| AP-2 | Increase | 8.1 |
| ISRE(TransTF) | Decrease | 0.24 |
| Antiox. RE | Decrease | 0.32 |
| HBS/HAS | Decrease | 0.2 |
| RSRFC4 | Increase | 6.5 |
| Skn | Increase | 4.8 |
| ICSBP | Decrease | 0.3 |
| WT1 | Increase | 8.9 |
Ratio values are given compared with control group.
*
Ratio can not be calculated since signal of the control group was below detectable limits