Figure 2.

PHB is upregulated in models of ischemic preconditioning in vivo and in vitro. A, PHB is upregulated in mitochondria of brains preconditioned by BCCAO. B, Quantification of band intensity in A (*p < 0.05; n = 7). C, PHB is upregulated in cell lysates from neuronal cultures preconditioned with OGD. D, Quantification of band intensity in C (*p < 0.05; n = 7/group). E, Neurons preconditioned with a nonlethal OGD episode are more resistant to damage produced by lethal OGD. Cell viability was assessed by morphological criteria 24 h after lethal OGD (*p < 0.05; n = 4/group with >1000 cells/group). Error bars indicate SEM.