Table 1.
Hemodynamics and arterial blood gas analysis.
| Baseline | T = 0 hr | T = 2 hr | T = 4 hr | ||
|---|---|---|---|---|---|
| Mean arterial pressure (mmHg) | LVt acid# | 81 ± 4.0 | 84 ± 3.9 | 91 ± 3.8 | 77 ± 2.6* |
| HVt acid# | 77 ± 3.4 | 88 ± 5.5 | 87 ± 2.7 | 72 ± 2.3 | |
| LVt sepsis | 75 ± 1.7 | 74 ± 2.6 | 68 ± 2.2 | 69 ± 2.5 | |
| HVt sepsis | 74 ± 2.2 | 80 ± 2.2 | 66 ± 2.1 | 65 ± 0.9 | |
| Heart rate (bpm) | LVt acid | 269 ± 10 | 267 ± 11 | 332 ± 10 | 336 ± 12 |
| HVt acid | 289 ± 8 | 249 ± 14 | 328 ± 7 | 345 ± 11 | |
| LVt sepsis | 322 ± 9$ | 322 ± 9 | 346 ± 15 | 353 ± 8 | |
| HVt sepsis | 350 ± 14$ | 360 ± 12 | 361 ± 10 | 350 ± 9 | |
| pH | LVt acid | 7.41 ± 0.02 | 7.39 ± 0.01 | 7.37 ± 0.01 | 7.35 ± 0.01 |
| HVt acid | 7.41 ± 0.02 | 7.38 ± 0.01 | 7.40 ± 0.01 | 7.30 ± 0.02 | |
| LVt sepsis | 7.44 ± 0.01 | 7.42 ± 0.01 | 7.38 ± 0.02 | 7.33 ± 0.02 | |
| HVt sepsis | 7.44 ± 0.01 | 7.44 ± 0.01 | 7.41 ± 0.02 | 7.38 ± 0.02 | |
| PaCO2 (mmHg) | LVt acid | 39.4 ± 1.1 | 42.9 ± 1.8 | 42.4 ± 1.4 | 42.2 ± 1.4 |
| HVt acid | 40.0 ± 1.2 | 43.8 ± 2.3 | 40.3 ± 1.3 | 45.8 ± 2.1 | |
| LVt sepsis | 37.1 ± 0.8 | 38.7 ± 1.78 | 38.0 ± 1.0 | 42.2 ± 1.0 | |
| HVt sepsis | 37.0 ± 1.5 | 38.7 ± 1.6 | 36.0 ± 0.7 | 36.0 ± 0.6 |
Mean arterial pressure (MAP) and heart rate in rats during 4 h of mechanical ventilation after acid instillation or during sepsis with low tidal volume (LVt) (6 mL/kg), with a positive end-expiratory pressure (PEEP) of 5 cm H2O or high tidal volume (HVt) (15 mL/kg) without PEEP. Data represent mean ± SEM. # p < 0.001 for model compared to sepsis during the experiment, * p = 0.01 compared to HVt sepsis, $ p = 0.001 for model compared to acid only at baseline.