Table 2.
Plasma concentrations of mediators.
| Acid | LVt acid | HVt acid | Sepsis | LVt sepsis | HVt sepsis | |
|---|---|---|---|---|---|---|
| IL-6 (pg/ml) | 321 ± 13 | 1113 ± 387# | 758 ± 209# | 312 ± 8 | 643 ± 190 | 393 ± 31 |
| TNF-α (pg/ml) | 39 ± 3 | 61 ± 9* | 62 ± 12* | 38 ± 2 | 42 ± 4 | 43 ± 10 |
| MIP-2 (pg/ml) | 4.6 ± 0.1 | 5.4 ± 0.4 | 5.2 ± 0.03 | 4.7 ± 0.3 | 5.0 ± 0.3 | 6.0 ± 0.8 |
| sICAM-1 (ng/ml) | 4.0 ± 0.3 | 30.9 ± 2.8$ | 22.6 ± 2.8$ | 31.4 ± 6.0 | 41.2 ± 6.7 | 32.2 ± 2.4 |
| aPAI-1 (ng/ml) | 0.0 ± 0.0 | 20.8 ± 2.1 | 12.5 ± 5.7 | 9.8 ± 3.0 | 18.5 ± 2.7 | 22.5 ± 3.1 |
Plasma concentrations of interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), macrophage inflammatory protein-2 (MIP-2), soluble intercellular adhesion molecule-1 (sICAM-1) and active plasminogen activator inhibitor-1 (aPAI-1) in rats ventilated for 4 h after acid instillation or during sepsis with low tidal volume (LVt) (6 mL/kg), with a positive end-expiratory pressure (PEEP) of 5 cm H2O or high tidal volume (HVt) (15 mL/kg) without PEEP. HVt after acid instillation did not affect plasma mediator levels. Acid instillation increased IL-6 and TNF-α plasma concentrations as compared to sepsis. Levels of sICAM-1 were lower in the acid group. Data represent mean ± SEM. # p=0.002 for model compared to LVt and HVt sepsis, * p=0.005 for model compared to LVt and HVt sepsis, $ p=0.031 for model compared to LVt and HVt sepsis.