Table 3.
Median and dispersion statistics of the posterior distributions of the demographic parameters
| Parameter | Prior | Median | 95% CI |
|---|---|---|---|
| NeYRI | U(500,10000) | 5070 | (2400 - 8930) |
| NeCEU | U(500,5000) | 1630 | (130 - 6900) |
| NeCHB | U(500,5000) | 4720 | (1920 - 7650) |
| NeCEU_CHB | U(500,5000) | 4390 | (1420 - 8890) |
| NeA | U(500,5000) | 4800 | (2160 - 8900) |
| tSplitCEU_CHB | U(0.17, 0.83)b | 45,250 | (11,500 - 63,250) |
| tSplitOAA | U(100,000, 325,000) | 52,250 | (50,250 - 76,000) |
CI, confidence interval.
aEstimated by approximate bayesian computation/Markov chain Monte Carlo (ABC-MCMC) from regions of 10 kb each from 50 genes from the Environmental Genome Project database with a burn-in of 1,000 simulations, 9,000 retained simulations and a thinning of 9. The total number of iterations retained for estimating the posterior distributions was 1,000. Times are computed in years as the number of generations multiplied by an estimated generation time of 25 years, and a scaling factor of 10 that was used (μ was set constant to 2.35 × 10-7 after scaling by 10). Effective population sizes are in number of diploid individuals after correcting by the scaling factor of 10.
bTime of split of CEU and CHB as a function of the remaining time after the out-of-Africa split. A value of 1 would indicate that CEU and CHB split just after the out-of-Africa split.