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Competitive inhibition of d-Trp-OPE- and CCK-stimulated CCK receptor internalization by coexpressing peptides representing portions of IL3C. Representative fluorescence images show Alexa-d-Trp-OPE (2 nM; top) and Alexa-CCK (100 nM; bottom) internalization after occupation of the rCCK1R expressed on CHO-CCK1R cells coexpressing IL3C, as well as fragments of this peptide (IL3C.1 and IL3C.2). Images are typical of data observed in 3 independent experiments. Scale bars, 20 μm.
