Fig. 7.

Trafficking and Cl⁻ currents of chimeras between ANO1 and ANO7. A: cartoon of chimeric constructs. ANO1 (black). ANO5 (red). Chimeras are named based on the position of the residues included from either ANO1 (A1) or ANO7 (A7); for example, mA1(1-279)hA7-end includes the first 279 residues from ANO1 with the remaining residues belonging to ANO7. B: average current amplitudes of ANO1-ANO7 chimeras in transiently transfected HEK293 cells in response to 24 μM intracellular [Ca²⁺]. C: confocal images showing localization of GFP-tagged ANO1-ANO7 chimeras counterstained with WGA.