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. 2011 Oct 19;40(4):1767–1777. doi: 10.1093/nar/gkr808

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — The Lin28 protein, pre-let-7g RNA and related sequences used in this study. (A) Schematic representation of the primary structures of Lin28 and deletion fragments. The gray boxes delineate sequences of known RNA-binding motifs: a cold shock domain (CSD) and a pair of retroviral–type CCHC zinc-binding domains (ZBD1 and ZBD2). (B) Schematic representation of pre-let-7g, indicating the regions (gray boxes) from which TL-let-7g and duplex let-7g GNRA were derived. (C and D) Primary and secondary structures of the (C) duplex let-7g GNRA and (D) TL-let-7g. Nucleotides within the mature miRNA sequence are in blue and non-natural nucleotides are shown in lowercase. In (D), site-specific mutations of TL-let-7g are in red and regions that were replaced by alternative structured elements are boxed.