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. 2011 Nov 2;40(4):1407–1423. doi: 10.1093/nar/gkr810

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Examples of covariation of conserved base triples observed at corresponding positions in E. coli (blue) and T. thermophilus (orange) from 23S rRNA (Upper row) and 16S rRNA (Lower row). Upper row (A): Conserved tWW/cSS base triple in 23S rRNA nucleotides 430/234/219, which is AUA in E.c. and GCG in T. th. (B): Conserved cWW/cHS base triple in 23S rRNA position 757/740/739, which is GCA in E.c. and UUG in T. th. (C): Conserved cWW/cSW base triple in 23S rRNA position 418/409/226, which is GCA in E.c. and CGG in T. th. Lower row (D): Conserved cWW/cHS base triple in 16S rRNA position 644/595/596, which is UAA in E.c. and GCG in T. th. (E): Conserved cWW/cSS base triple in 16S rRNA position 1326/1311/1268, which is AUG in E. coli and GCA in T. th. Structures were taken from the following PDB files: E. coli 23S rRNA, 2QBE (25); E. coli 16S rRNA, 2QAN (25) T. th. 23S rRNA, 3I8I (27) and T. th. 16S rRNA, 1J5E (26).