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. 2011 Oct 27;40(4):1828–1840. doi: 10.1093/nar/gkr867

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Comparison of A3^OB and A6. (A) Superposition of the A3^OB and A6 chains from the A3^OB-A6 heterodimer. The A3^OB chain is shown in magenta; A6 from the A3^OB–A6 heterodimer in yellow. Note the large conformational differences in the L23 loop, as well as in the β4–β5 hairpin. (B) Superposition of the A3^OB–A6 and A6–A6 dimers. A view along the pseudodyad of the heterodimer. The A3^OB chain is shown in magenta; A6 from the A3^OB–A6 heterodimer in yellow; both A6 subunits from the A6–A6 homodimer in blue (PDB-ID: 3K7U) (54). (C) Superposition of A6 in the A3^OB-A6 heterodimer and A6 in the A6 homodimer. A6 from the heterodimer is depicted in yellow; A6 from the homodimer in blue (PDB-ID: 3K7U) (54). Note that the L23 loop, as well as the β4–β5 hairpin of A6 is better ordered in the A3^OB-A6 heterodimer than in the A6 dimer.