Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Oct 22;40(4):1485–1498. doi: 10.1093/nar/gkr868

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 7. — Model for the cooperation of FANCJ with REV1 and with the WRN and BLM proteins in replicating a G-quadruplex. (A) Cooperation of FANCJ with REV1. We have previously suggested that REV1 may help destabilize G-quadruplex structures (14). This could facilitate unwinding by FANCJ, which will act from the opposite side of the G-quadruplex structure. (B) Cooperation of FANCJ with WRN or BLM. Since the helicase activities of WRN and BLM helicases have the opposite polarity to FANCJ, this suggests a model by which they also act from the other end of the quadruplex, possibly simultaneously with FANCJ. DNA synthesis across the remainder of the G4 DNA sequence may then be affected by one of the replicative polymerases.