Table 1.

Association of dysregulated genes with G4 DNA motifs

	Control	rev1	fancj	rev1/fancj	wrn/blm	rev1 and wrn/blm	fancj and wrn/blm
Fraction of genes with ≥1 G4 DNA motif	0.69	0.85	0.88	0.83	0.85	0.83	0.77
n	135	93	130	116	164	80	141
P		0.0013	0.0002	0.0075	0.0013	0.036	0.135
G4 DNA motifs per gene	2.63	4.29	3.78	4.18	3.15	4.79	3.31
P		0.005	0.0003	0.0059	0.0186	0.0053	0.03

G4 DNA sequences were identified in the gene body plus 1 kb upstream using pre-existing annotations of the chicken genome in ENSEMBL uploaded from www.quadruplex.org. Genes were selected on the basis of an increase or decrease in probe intensity by ≥0.25 log₂ units with P < 0.05. The control set comprises randomly selected probes that exhibit no change between WT and any of the mutants.