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. 2012 Feb 6;122(3):833–843. doi: 10.1172/JCI60256

Figure 5. Heat maps displaying genes differentially regulated by cyclin D1 in transgenic mouse models.

Figure 5

(A) Genes differentially regulated between rtTA/CCND1 tumors (n = 3) and normal mouse mammary glands from rtTA control mice (n = 2), visualized by hierarchical clustering. (B) The most highly differentially regulated genes (Fold>2, B>3) were enriched for CIN in the rtTA/CCND1 profile (P < 0.0001). (C) Genes differentially regulated between MMTV-CCND1–induced tumors (n = 3) and normal mouse mammary glands (n = 2), visualized by hierarchical clustering. (D) The most highly differentially regulated genes (Fold>2, B>4) were enriched for CIN in the MMTV-CCND1 profile (P < 0.0001).