Table 2.
Average Daily Feed Intake (ADFI) | Average Daily Gain (ADG) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Marker1 | Gene2 | Position3 | IUB | # Genotypes4 | MAF | Effect5 | P-value | Correction6 | Effect | P-value | Correction |
ARS-BFGL-NGS-77584 | 37855236 | R | 1182 | G = 0.10 | -0.026 | 0.8 | NS | -0.0078 | 0.7 | NS | |
After2Run10KSet7323 | 37856744 | Y | 1075 | T = 0.30 | -0.14 | 0.01 | NS | -0.029 | 0.01 | NS | |
Hapmap31601-BTC-034240 | 37859827 | R | 1076 | G = 0.28 | -0.15 | 0.005 | NS | -0.033 | 0.004 | NS | |
Hapmap28705-BTC-034230 | 37862818 | S | 1090 | G = 0.31 | -0.14 | 0.010 | NS | -0.033 | 0.003 | NS | |
Hapmap25169-BTC-034210 | 37870369 | R | 1186 | A = 0.30 | -0.15 | 0.006 | NS | -0.033 | 0.003 | NS | |
Hapmap30444-BTC-052947 | 37875093 | Y | 1164 | C = 0.49 | 0.16 | 0.004 | NS | 0.036 | 0.002 | NS | |
After2Run10KSet5598 | 37875791 | Y | 1186 | C = 0.30 | -0.14 | 0.01 | NS | -0.032 | 0.004 | NS | |
Hapmap32743-BTC-052998 | 37879284 | R | 1011 | A = 0.23 | -0.073 | 0.2 | NS | -0.024 | 0.04 | NS | |
Hapmap23977-BTC-053017 | 37880952 | M | 1176 | A = 0.30 | -0.15 | 0.006 | NS | -0.032 | 0.005 | NS | |
79140_312 | LAP3 | 37964162 | INDEL | 1165 | DEL = 0.09 | 0.11 | 0.2 | NS | -0.013 | 0.5 | NS |
Hapmap56977-ss46527055 | LAP3 | 37967630 | R | 1192 | A = 0.13 | -0.051 | 0.5 | NS | -0.013 | 0.4 | NS |
79152_265 | LAP3 | 37977863 | Y | 1181 | C = 0.33 | -0.020 | 0.7 | NS | -0.021 | 0.05 | NS |
79154_194 | LAP3 | 37979109 | Y | 1078 | T = 0.38 | -0.0072 | 0.9 | NS | -0.021 | 0.06 | NS |
79154_347 | LAP3 | 37979262 | S | 1098 | C = 0.34 | -0.022 | 0.7 | NS | -0.021 | 0.04 | NS |
79158_103 | LAP3 | 37984197 | S | 1193 | G = 0.34 | 0.026 | 0.6 | NS | 0.021 | 0.05 | NS |
79158_104 | LAP3 | 37984198 | R | 1190 | G = 0.33 | -0.021 | 0.7 | NS | -0.020 | 0.07 | NS |
79160_105 | LAP3 | 37985986 | Y | 1127 | T = 0.34 | -0.0086 | 0.9 | NS | -0.019 | 0.08 | NS |
79162_241 | LAP3 | 37986804 | K | 1124 | T = 0.37 | -0.0064 | 0.9 | NS | -0.22 | 0.05 | NS |
79162_246 | LAP3 | 37986809 | Y | 1197 | C = 0.34 | -0.020 | 0.7 | NS | -0.21 | 0.04 | NS |
ARS-BFGL-NGS-44699 | 38011603 | S | 1183 | C = 0.10 | -0.085 | 0.3 | NS | -0.021 | 0.2 | NS | |
BTA-100891 | 38076964 | Y | 1063 | T = 0.26 | -0.083 | 0.1 | NS | -0.028 | 0.008 | NS | |
83704_2347 | NCAPG | 38157198 | R | 1085 | A = 0.42 | 0.18 | 0.0006 | 0.03 | 0.046 | 2.E-05 | 0.0009 |
83704_366 | NCAPG | 38157330 | R | 1187 | G = 0.12 | -0.11 | 0.2 | NS | -0.013 | 0.4 | NS |
83708_361 | NCAPG | 38158932 | Y | 1092 | C = 0.41 | 0.17 | 0.001 | 0.05 | 0.045 | 4.E-05 | 0.002 |
83712_1687 | NCAPG | 38163729 | R | 1004 | G = 0.47 | -0.16 | 0.003 | NS | -0.045 | 9.E-05 | 0.004 |
83714_2247 | NCAPG | 38164403 | K | 1132 | G = 0.34 | 0.21 | 8.E-05 | 0.004 | 0.059 | 1.E-07 | 5.E-06 |
83724_658 | NCAPG | 38180790 | Y | 1100 | C = 0.41 | 0.17 | 0.001 | 0.05 | 0.045 | 5.E-05 | 0.002 |
83730_778 | NCAPG | 38195339 | M | 1022 | A = 0.42 | 0.17 | 0.003 | NS | 0.058 | 1.E-06 | 0.00005 |
83732_316 | NCAPG | 38195743 | R | 1050 | G = 0.42 | 0.14 | 0.008 | NS | 0.044 | 1.E-04 | 0.005 |
Hapmap24122-BTC-041153 | 38217816 | K | 1193 | G = 0.35 | 0.22 | 1.E-05 | 0.0005 | 0.059 | 2.E-08 | 9.E-07 | |
Hapmap24041-BTC-041151 | 38220879 | K | 1192 | T = 0.35 | 0.22 | 1.E-05 | 0.0005 | 0.059 | 2.E-08 | 9.E-07 | |
Hapmap31609-BTC-041148 | 38223329 | R | 1192 | A = 0.38 | 0.17 | 0.0005 | 0.02 | 0.045 | 1.E-05 | 0.0005 | |
Hapmap28154-BTC-0411348 | LCORL | 38228679 | R | 935 | C = 0.38 | 0.18 | 0.0003 | 0.01 | 0.045 | 2.E-05 | 0.0009 |
Hapmap27082-BTC-041131 | LCORL | 38233962 | R | 1121 | G = 0.37 | 0.18 | 0.0002 | 0.009 | 0.047 | 4.E-06 | 0.0002 |
Hapmap26855-BTC-041123 | LCORL | 38239191 | R | 1075 | G = 0.33 | 0.21 | 8.E-05 | 0.004 | 0.058 | 1.E-07 | 5.E-06 |
Hapmap23341-BTC-041113 | LCORL | 38250098 | K | 1161 | T = 0.36 | 0.21 | 4.E-05 | 0.002 | 0.056 | 1.E-07 | 5.E-06 |
81441_243 | LCORL | 38255270 | S | 822 | G = 0.28 | -0.24 | 5.E-06 | 0.0002 | -0.058 | 2.E-07 | 9E-06 |
81435_188 | LCORL | 38284737 | Y | 892 | C = 0.38 | 0.17 | 0.0004 | 0.02 | 0.042 | 3.E-05 | 0.001 |
Hapmap28589-BTC-0410459 | LCORL | 38300298 | S | 1190 | G = 0.33 | 0.22 | 2.E-05 | 0.0009 | 0.061 | 1.E-08 | 5.E-07 |
Hapmap33629-BTC-041038 | LCORL | 38313142 | Y | 999 | T = 0.30 | 0.22 | 2.E-05 | 0.0009 | 0.059 | 5.E-08 | 2.E-06 |
Hapmap28835-BTC-041022 | LCORL | 38326993 | S | 1061 | G = 0.18 | -0.12 | 0.07 | NS | -0.027 | 0.04 | NS |
81419_461 | LCORL | 38342145 | M | 1058 | C = 0.05 | -0.17 | 0.1 | NS | -0.046 | 0.04 | NS |
Hapmap33694-BTC-041005 | LCORL | 38342183 | R | 1190 | G = 0.16 | -0.10 | 0.1 | NS | -0.038 | 0.005 | NS |
81405_2829 | LCORL | 38376731 | M | 1196 | A = 0.33 | 0.22 | 2.E-05 | 0.0009 | 0.061 | 1.E-08 | 5.E-07 |
Hapmap33650-BTC-073421 | 38409471 | Y | 1041 | C = 0.40 | -0.14 | 0.004 | NS | -0.036 | 0.0003 | 0.01 | |
Hapmap31943-BTC-050642 | 38427989 | Y | 1181 | C = 0.08 | -0.11 | 0.2 | NS | -0.039 | 0.02 | NS | |
BTB-00249053 | 38481012 | Y | 1183 | T = 0.24 | -0.12 | 0.03 | NS | -0.029 | 0.01 | NS |
1 Name of publicly available markers from the following references: Van Tassell CP et al. [26], Bovine HapMap Consortium et al. [27], and Bovine Genome Sequencing and Analysis Consortium et al. [28]
2 SNP located within a gene locus are presented in this column. The gene loci for LAP3, NCAPG, and LCORL are: 37,961,725 - 37,987,164 bp, 38,153,047-38,199,153 bp, and 38,227,955-38,378,385 bp on the Btau 4.0 genome assembly.
3 Position based on the Btau 4.0 Bovine Genome Assembly.
4 Number of genotypic calls used for statistical analysis.
5 ADFI and ADG effects are displayed as kg/d. Effects are presented for the minor allele.
6 Correction for multiple testing performed by multiplying the P-values by the number of markers tested (n = 47). NS = not significant, P-value > 0.05.
7 Markers evaluated in Setoguchi et al. [8] and Eberlein et al. [11].
8 Marker evaluated in Charolais and German Holstein population in Eberlein et al. [11].
9 Markers in bold font, Hapmap28589-BTC-041045 and 81405_282, were significantly associated with ADG in the validation population of animals (P = 0.04 and 0.03, respectively).