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. Author manuscript; available in PMC: 2012 Feb 27.
Published in final edited form as: J Pathol. 2010 Oct;222(2):138–147. doi: 10.1002/path.2746

Figure 1. Organisation of the VEGF-A gene.

Figure 1

A. Gene structure. TSS=transcriptional start site. B. mRNA species. Alternative splicing of VEGF-A gene in the terminal exon results in two families of isoforms, the pro-angiogenic VEGFxxx, and the anti-angiogenic VEGFxxxb isoforms. AUG= start site for translation, UTR=untranslated region, pA = poly adenylation site. C. Protein structure of two major isoforms of each family. This C-terminal splicing leads to an alternative last six amino acids (CDKPRR or SLTRKD). The isoforms are termed according to the amino acid number of the resulting protein (xxx). HSPG=heparin sulphate proteoglycan, R1=VEGF receptor 1, R2 =VEGF Receptor 2 (not to scale).