Table 1. Neuroblastoma cell lines.

The cell types are named N for neuroblastic, S for non-neuronal, substrate-adherent, and I for the cell type that is intermediate in morphology between N and S. S-cells form no tumours in nude mice. In contrast, N-type cells form tumours in athymic mice with a frequency of 12%, I-type cells have the highest malignant potential, forming tumours in 80% of mice. SH-IN, SH-SY5Y and SH-EP are subclones of the same cell line: SK-N-SH (20).

CELL LINE	CELL TYPE	MYCN	TUMORIGENESIS
BE(2)-C	I-type	Amplified	Yes
IMR-32	N-type	Amplified	Yes
SH-IN	I-type	Non amplified	Yes
SH-SY5Y	N-type	Non amplified	Yes
SH-EP	S-type	Non amplified	No