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. Author manuscript; available in PMC: 2013 Jan 17.
Published in final edited form as: Circulation. 2011 Dec 9;125(2):298–307. doi: 10.1161/CIRCULATIONAHA.111.059097

Figure 2.

Figure 2

Catecholamine-releasing effect of natriuretic peptides and sodium nitroprusside (SNP). A. Concentration-response curves for the NE-releasing effects elicited by BNP, ANP and SNP (3–100 nM) in sympathetic nerve terminals (cardiac synaptosomes) isolated from guinea pig hearts. B: Concentration-response curves for the DA-releasing effects elicited by BNP, ANP and SNP (0.1–100 nM) in NGF-differentiated PC12 cells. In A, points are mean increases in NE release above basal level (± SEM; n=10–16, 12 and 8–12 for a, b and c, respectively). **, P<0.01 and ***, P<0.001 from lowest concentrations of BNP, ANP or SNP by unpaired t-test. In B, points are mean increases in DA release above basal level (± SEM; n=7–10, 6–7 and 6–10 for a, b and c, respectively). *, P<0.05, **, P<0.01 and ***, P<0.001 from lowest concentrations of BNP, ANP or SNP by unpaired t-test. Basal NE and DA levels were 1.44 ± 0.04 (± SEM; n=46) and 6.82 ± 0.75 pmol/mg protein (± SEM; n=7), respectively.