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. 2012 Feb 22;122(3):948–962. doi: 10.1172/JCI60455

Figure 5. DYRK1A and CHAF1B are overexpressed in DS-TMD and DS-AMKL.

Figure 5

(A) GSEA of the 33 trisomic human orthologs contained in Ts1Rhr mice derived from an available gene expression profile data set (62), comparing their relative expression in non–DS-AMKL compared with that in DS-AMKL and their relative enrichment. (B) Ranked list of chromosome 21 genes of the DSCR enriched in DS-AMKL compared with those in non–DS-AMKL from both data set 1 (shown in A) and data set 2 (26). (C) DYRK1A (probe set 209033_s_at), CHAF1B (probe set 204775_s_at), HLCS (probe set 209399_s_at), and ERG (probe set 211626_s_at) relative expression in pediatric AML (n = 9), non–DS-AMKL (n = 43), DS-AMKL (n = 20), and TMD (n = 8) (GC_RMA normalized probe values extracted from ref. 26). Gene expression in each sample (individual colored symbols), medians (horizontal bars), and P values (t test) are shown.