Figure 5.

Adverse events of interest. Exposure-adjusted incidence rate and risk difference of thyroid neoplasm, pancreatitis, and renal impairment (exenatide twice daily n = 3261, pooled comparator n = 2333) and major adverse cardiac events analysis (n = 2316, n = 1629, respectively). Thyroid neoplasm includes benign neoplasm of thyroid gland and malignant thyroid neoplasm. Pancreatitis includes acute pancreatitis and chronic pancreatitis. Renal impairment includes renal failure. Major adverse cardiac events include stroke, myocardial infarction, cardiac mortality, acute coronary syndrome, and revascularization procedures.

Notes: ^a95% confidence interval for the risk difference (exenatide incidence rate [%] minus pooled comparator incidence rate [%]); ^bmajor adverse cardiac events analysis: risk ratio and 95% confidence interval for the risk ratio.

Abbreviations: EAIR, exposure-adjusted incidence rate; BID, twice daily, MACE, major adverse cardiac events; PY, patient years.