Table 1.
Particle size, polydispersity index (PI) and zeta potential of SSMs before and after freeze-drying
| PEGylated polymer and/or BDP-SSMs | Concentrations (mM) | Particle size (nm) | PI | Zeta potential (mV) | |||
|---|---|---|---|---|---|---|---|
|
|
|
|
|||||
| Before FD | After FD | Before FD | After FD | Before FD | After FD | ||
| PEG5000-DSPE | 5 | 20.30 ± 1.31 | 20.31 ± 1.32 | 0.20 ± 0.02 | 0.21 ± 0.02 | −28.70 ± 2.21 | −27.18 ± 2.50 |
| 10 | 17.33 ± 2.08 | 18.55 ± 2.25 | 0.20 ± 0.02 | 0.21 ± 0.01 | −45.51 ± 2.35 | −45.69 ± 1.63 | |
| BDP: PEG5000-DSPE | 0.4:5 (Drug: PEGylated polymer concentration) | 19.99 ± 0.99 | 19.89 ± 0.67 | 0.21 ± 0.02 | 0.22 ± 0.02 | −27.70 ± 2.25 | −28.03 ± 2.05 |
Abbreviations: BDP, beclomethasone dipropionate; BDP-SSMs, sterically stabilized phospholipid nanomicelles containing beclomethasone dipropionate; FD, freeze drying; PEG, polyethylene glycol; PEG5000-DSPE, 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 5000); SSMs, sterically stabilized phospholipid nanomicelles.