Table 1.
Gene | SIFT | PolyPhen-2 | Binary | Unweighted | Number of SNPs | Number of nonsynonymous SNPs |
---|---|---|---|---|---|---|
FAM13A1 | 0.0002 | 0.0001 | 0.0007 | 0.0003 | 34 | 23 |
DGKZ | 0.0002 | 0.0005 | 0.0002 | 0.0004 | 22 | 15 |
TRIM42 | 0.0003 | 0.0002 | 0.0009 | 0.0032 | 39 | 30 |
ADAM15 | 0.0003 | 0.0003 | 0.0016 | 0.0004 | 30 | 20 |
FLT1 | 0.0003 | 0.0007 | 0.0002 | 0.0002 | 35 | 20 |
GRIA4 | 0.0004 | 0.0003 | 0.0004 | 0.0066 | 18 | 6 |
IRF6 | 0.0005 | 0.0005 | 0.0021 | 0.0119 | 15 | 7 |
HDAC4 | 0.0007 | 0.0144 | 0.0011 | 0.0010 | 36 | 16 |
GDF15 | 0.0009 | 0.0006 | 0.0040 | 0.0006 | 10 | 6 |
SUSD2 | 0.0009 | 0.0008 | 0.0015 | 0.0005 | 45 | 29 |
All genes had tied rank 1 by the mixture model combining both SIFT-based and PolyPhen-2-based VT test p-values. P-values were obtained from 10,000 permutations.