Table 1.
Gene | Number of variants | Principal components and collapsing method | Weight-based collapsing method | Step-up method | |
---|---|---|---|---|---|
Total | With effect | ||||
ARNT | 18 | 5 | 0.044 | 0.066 | 0.041 |
ELAVL4 | 10 | 2 | 0.177 | 0.303 | 0.388 |
FLT1 | 35 | 11 | 4 × 10−21 | <10−5 | <10−5 |
FLT4 | 10 | 2 | 0.132 | 0.182 | 0.186 |
HIF1A | 8 | 4 | 0.008 | 0.091 | 0.074 |
HIF3A | 21 | 3 | 0.51 | 0.488 | 0.320 |
KDR | 16 | 11 | 0.003 | 0.587 | 0.059 |
VEGFA | 6 | 1 | 0.289 | 0.2345 | 0.262 |
VEGFC | 1 | 1 | 0.054 | 0.067 | 0.080 |