Table 1.
Top potentially interests genes (PIGs) with SNPs associated with Q1 in replicate 137 of GAW17 exon sequencing data (unrelated individuals)
| Gene | Chromosome | Total Number of SNPs | Distance (bp) | Crude model | Adjusted model 1a | Adjusted model 2b | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of SNPs with p < 2.04 × 10−6 | Number of SNPs with p < 0.10 | Highest p (SNP) | Number of SNPs with p < 2.04 × 10−6 | Number of SNPs with p < 0.10 | Highest p (SNP) | Number of SNPs with p < 2.04 × 10−6 | Number of SNPs with p < 0.10 | Highest p (SNP) | ||||
| FLT1 | 13 | 35 | 16,389 | 2 (C13S522 n, C13S523 n) | 10 (8 n, 2 s) | 3.41 × 10−18 (C13S523) | 3 (C13S522 n, C13S523 n, C13S524 n) | 11 (7 n, 4 s) | 5.64 × 10−21 (C13S423) | 2 (C13S522 n, C13S523 n) | 11 (7 n, 4 s) | 2.10 × 10−11 (C13S423) |
| FADS3 | 11 | 9 | 15,457 | 1 (C11S3071 n) | 1 (1 n) | 2.37 × 10−7 (C11S3071) | 1 (C11S3071 n) | 2 (1 n, 1 s) | 1.33 × 10−7 (C11S3071) | 1 (C11S3071 n) | 1 (1 n) | 8.68 × 10−7 (C11S3071) |
| C5ORF25 | 5 | 22 | 55,401 | 1 (C5S4371 n) | 2 (1 n, 1 s) | 3.99 × 10−5 (C5S4371) | 1 (C5S4371 n) | 2 (1 n, 1 s) | 3.45 × 10−7 (C5S4371) | 0 | 2 (1 n, 1 s) | 4.56 × 10−5 (C5S4371) |
| AKAP13 | 15 | 163 | 223,193 | 1 (C15S4393 n) | 10 (8 n, 2 s) | 1.58 × 10−6 (C15S4393) | 1 (C15S4393 n) | 11 (8 n, 3 s) | 1.37 × 10−6 (C15S4393) | 0 | 14 (10 n, 4s) | 3.89 × 10−5 (C15S4393) |
| OR2T34 | 1 | 16 | 495 | 3 (C1S11528 n, C1S11529 s, C1S11541 n) | 11 (8 n, 3 s) | 8.06 × 10−9 (C1S11541) | 3 (C1S11528 n, C1S11529 s, C1S11541 n) | 11 (8 n, 3 s) | 2.80 × 10−10 (C1S11541) | 0 | 6 (3 n, 3s) | 3.28 × 10−4 (C1S11541) |
a Adjusted for Age, Sex, Smoking, Pop1.
b Adjusted for Age, Sex, Smoking, Pop1 and top 12 principal components (PCs).
c n=nonsynonymous SNP; s=synonymous SNP