Table 3.
Whole-exome minor allele load results
| Procedure | Number of SNPs | Minor allele load | Sex | Ethnicity | |||
|---|---|---|---|---|---|---|---|
| Odds ratio | p-value | Odds ratio | p-value | Odds ratio | p-value | ||
| All SNPs | 24,487 | 1.296 | 2.05 × 10−3 | 1.096 | 0.28 | 1.405 | 7.15 × 10−5 |
| MAF ≥ 0.05 | 3,126 | 1.247 | 8.63 × 10−3 | 1.093 | 0.30 | 1.514 | 1.59 × 10−5 |
| MAF < 0.05 | 21,361 | 1.338 | 1.25 × 10−3 | 1.088 | 0.32 | 1.289 | 6.12 × 10−3 |
| MAF < 0.01 | 18,175 | 1.326 | 2.68 × 10−3 | 1.093 | 0.30 | 1.274 | 0.018 |
| Inverse weighting | 24,287 | 1.329 | 1.22 × 10−3 | 1.095 | 0.29 | 1.323 | 1.71 × 10−3 |
| Nonsynonymous | 13,572 | 1.287 | 2.36 × 10−3 | 1.090 | 0.31 | 1.426 | 3.17 × 10−5 |
| Synonymous | 10,113 | 1.311 | 1.81 × 10−3 | 1.099 | 0.27 | 1.360 | 4.06 × 10−4 |
| BLOSUM weighting | 24,487 | 1.296 | 2.00 × 10−3 | 1.094 | 0.29 | 1.404 | 7.38 × 10−5 |
Each row represents a different minor allele load procedure. The number of SNPs analyzed depends on the inclusion threshold or functional category for each procedure.