Table 1.
Trait | Gene | Population | Tag SNP | Rare SNP collapsing statistic ri/ni | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | Significance level for additive test | Estimated power for additive test | Mean effect estimate | Correlation between tag SNP and ri/ni | Mean effect estimate | |||||||
Over all data sets | Over data sets with significant tag effect | Relative bias (%) | Over all data sets | Over data sets with significant tag effect | Relative bias (%) | |||||||
Q1 | KDR | CEPH | C4S1878 | 0.001 | 0.15 | 0.63 | 0.93 | 49 | 0.41 | 5.51 | 6.19 | 12 |
DS | PIK3C2B | Tuscan | C1S9170 | 0.05 | 0.10 | 0.87 | 2.26 | 160 | 0.40 | 6.69 | 7.08 | 6 |
DS | PIK3C2B | Tuscan | C1S9171 | 0.05 | 0.10 | 0.87 | 2.26 | 160 | 0.40 | 6.69 | 7.08 | 6 |
DS | PTK2B | CEPH | C8S911 | 0.05 | 0.10 | 0.67 | 1.49 | 122 | 0.51 | 1.99 | 2.91 | 46 |
DS | PTK2B | Chinese | C8S925 | 0.05 | 0.06 | 0.21 | 1.23 | 476 | 0.47 | 0.34 | 1.53 | 350 |
Results for scenario 2. Values computed as described in the Results section. DS is disease status.