Table 1.
Heritability estimates for the affection status from polygenic models with different covariates
| Model | h2 (SE) | SC | KL |
|---|---|---|---|
| No covariance | 0.10 (0.07) | – | – |
| Age, Sex, Smoking, and interactions | 0.55 (0.16) | Age, Smoking | 0.27 |
| Q1, Q2, Q4, and interactions | 0.06 (0.18) (ns) | Q1, Q2, Q4 | 0.63 |
| Age | 0.53 (0.15) | Age | 0.24 |
| Smoking | 0.11 (0.08) | Smoking | 0.02 |
| Q1 | 0.17 (0.13) (ns) | Q1 | 0.32 |
| Q2 | 0.005 (0.07) (ns) | Q2 | 0.12 |
| Q4 | 0.60 (0.15) | Q4 | 0.27 |
| Q1 × Q2 | 0.03 (0.07) (ns) | Q1 × Q2 | 0.03 |
| Q1 × Q4 | 0.15 (0.08) | Q1 × Q4 | 0.02 |
| Q2 × Q4 | 0.11 (0.06) | Q2 × Q4 | 0.01 |
| Q4, Age | 0.58 (0.15) | Q4, Age | 0.27 |
| Q1, Q2 | 0.13 (0.13) (ns) | Q1, Q2 | 0.39 |
| Q2, Age | 0.42 (0.17) | Q2, Age | 0.44 |
The h2 column contains the heritability estimates of the affection status using the model defined in the model column. The SC column lists the covariates that were found to be significant in the model. The KL column gives the Kullback-Leibler R2 statistic. ns, nonsignificant.