Table 1.
Power for association using whole-exome or linkage region sequencing
| SNP | Gene | MAF | β | Power from WES (%) | Linked (%) | Power from LRS (%) |
|---|---|---|---|---|---|---|
| C4S4935 | VEGFC | 0.0007 | 1.35726 | 99.50 | 70.00 | 70.00 |
| C1S3181 | ELAVL4 | 0.0007 | 0.76911 | 0.50 | 0.00 | 0.00 |
| C4S1873 | KDR | 0.0007 | 0.58301 | 1.00 | 0.00 | 0.00 |
| C13S514 | FLT1 | 0.0007 | 0.56643 | 0.50 | 0.00 | 0.00 |
| C19S4831 | HIF3A | 0.0007 | 0.29287 | 1.00 | 1.00 | 0.00 |
| C1S6540 | ARNT | 0.0014 | 0.24129 | 2.50 | 0.00 | 0.00 |
| C13S320 | FLT1 | 0.0014 | 0.19605 | 0.50 | 0.00 | 0.00 |
| C6S2981 | VEGFA | 0.0022 | 1.20645 | 99.50 | 71.00 | 71.00 |
| C4S1861 | KDR | 0.0022 | 0.56311 | 0.00 | 0.00 | 0.00 |
| C4S1890 | KDR | 0.0022 | 0.42407 | 0.50 | 0.00 | 0.00 |
| C1S6533 | ARNT | 0.0115 | 0.5619 | 0.50 | 0.00 | 0.00 |
| C14S1734 | HIF1A | 0.0122 | 0.21203 | 0.50 | 0.00 | 0.00 |
| C13S431 | FLT1 | 0.0172 | 0.74136 | 13.50 | 0.00 | 0.00 |
| C4S1884 | KDR | 0.0208 | 0.29558 | 3.00 | 0.00 | 0.00 |
| C13S522 | FLT1 | 0.028 | 0.6183 | 7.00 | 0.00 | 0.00 |
| C13S523 | FLT1 | 0.0667 | 0.64997 | 33.00 | 0.00 | 0.00 |
| C4S1878 | KDR | 0.165 | 0.13573 | 4.50 | 0.00 | 0.00 |
β: estimate from association tests using a regression model; MAF: minor allele frequency; WES: whole-exome sequencing; LRS: linkage region sequencing