Table 1.
Distribution of causal minor alleles of Q1 and Q2 in the eight simulated pedigrees
| Gene | Family | Founder | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | Yes | No | |
| Q1 | ||||||||||
| ARNT | 3 | 2 | 0 | 0 | 6 | 0 | 0 | 0 | 4 | 7 |
| ELAVL4* | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| FLT1 | 0 | 0 | 5 | 0 | 28 | 16 | 13 | 12 | 28 | 46 |
| FLT4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| HIF1A* | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
| HIF3A* | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 2 |
| KDR | 14 | 37 | 43 | 31 | 6 | 0 | 93 | 0 | 55 | 169 |
| VEGFA* | 4 | 20 | 0 | 0 | 0 | 0 | 22 | 0 | 3 | 43 |
| VEGFC* | 0 | 0 | 0 | 0 | 0 | 0 | 31 | 0 | 1 | 30 |
| Q2 | ||||||||||
| BCHE | 4 | 0 | 0 | 0 | 1 | 0 | 2 | 2 | 5 | 4 |
| GCKR* | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| INSIG1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| LPL | 7 | 20 | 2 | 1 | 0 | 1 | 23 | 7 | 15 | 46 |
| PDGFD* | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 1 |
| PLAT | 0 | 1 | 2 | 0 | 0 | 3 | 0 | 0 | 4 | 2 |
| RARB | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| SIRT1 | 0 | 0 | 3 | 0 | 0 | 4 | 21 | 0 | 4 | 24 |
| SREBF1 | 16 | 21 | 0 | 5 | 9 | 12 | 8 | 0 | 13 | 58 |
| VLDLR | 2 | 0 | 0 | 0 | 11 | 0 | 6 | 0 | 4 | 15 |
| VNN1 | 35 | 60 | 27 | 15 | 24 | 17 | 77 | 0 | 54 | 201 |
| VNN3 | 24 | 17 | 27 | 0 | 21 | 0 | 42 | 42 | 46 | 127 |
| VWF | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 0 |
Asterisks indicate a single nonmonomorphic causal variant in the gene.