Table 3.
Percentage of phenotypic variance explained by causal genes of Q1 and Q2 in the eight simulated pedigrees
| Gene | Family | Total samples | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | ||
| Q1 | |||||||||
| ARNT | 1.3 | 0.1 | 0 | 0 | 2.0 | 0 | 0 | 0 | 0.3 |
| ELAVL4* | 0 | 0 | 0.8 | 0 | 0 | 0 | 0 | 0 | 0.08 |
| FLT1 | 0 | 0 | 1.4 | 0 | 22.2 | 11.9 | 2.3 | 14.6 | 5.8 |
| FLT4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| HIF1A* | 0 | 0 | 0 | 0 | 0.07 | 0 | 0 | 0 | 0.006 |
| HIF3A* | 0 | 0 | 0 | 0 | 0.4 | 0 | 0 | 0 | 0.04 |
| KDR | 0.8 | 1.6 | 0.9 | 1.8 | 0.5 | 0 | 1.6 | 0 | 1.2 |
| VEGFA* | 7.9 | 24.6 | 0 | 0 | 0 | 0 | 14.6 | 0 | 9.0 |
| VEGFC* | 0 | 0 | 0 | 0 | 0 | 0 | 23.8 | 0 | 7.9 |
| Q2 | |||||||||
| BCHE | 2.4 | 0 | 0 | 0 | 0.07 | 0 | 0.06 | 0.2 | 0.3 |
| GCKR* | 0.3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.04 |
| INSIG1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| LPL | 1.8 | 4.1 | 0.6 | 0.4 | 0 | 0.3 | 4.3 | 2.2 | 2.1 |
| PDGFD* | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 | 0 | 0.1 |
| PLAT | 0 | 0.02 | 0.7 | 0 | 0 | 0.08 | 0 | 0 | 0.1 |
| RARB | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| SIRT1 | 0 | 0 | 1.0 | 0 | 0 | 4.2 | 3.4 | 0 | 1.3 |
| SREBF1 | 3.8 | 2.2 | 0 | 1.2 | 2.1 | 3.0 | 1.2 | 0 | 1.7 |
| VLDLR | 0.6 | 0 | 0 | 0 | 4.6 | 0 | 3.1 | 0 | 1.2 |
| VNN1 | 1.6 | 2.8 | 1.8 | 1.4 | 1.7 | 1.3 | 2.1 | 0 | 1.9 |
| VNN3 | 1.7 | 1.2 | 1.9 | 0 | 1.6 | 0 | 2.1 | 7.8 | 2.2 |
| VWF | 0 | 0 | 0 | 1.7 | 0 | 0 | 0 | 0 | 0.2 |
Asterisks indicate a single nonmonomorphic causal variant in the gene.