Table 1.
In vitro sensitivity to QN and distribution of pfmdr1 polymorphisms of the 85 adapted parasites from Thai-Myanmar and Thai-Cambodia areas
| Area | No. | Mean QN | Mean | pfmdr1 mutations | ||||
|---|---|---|---|---|---|---|---|---|
| IC50 (nM) | pfmdr1 copy number | 86Y | 184F | 1034C | 1042D | 1246Y | ||
| Thai- Myanmar | 37 | 209.9 ± 117.1 | 2.9 ± 1.4* | 6 (16.2%) | 15 (40.5%) | 4 (10.8%) | 4 (10.8%) | - |
| Thai- Cambodia | 48 | 197.2 ± 128.9 | 1.2 ± 0.7 | 9 (18.8%) | 38 (79.2%)** | 10 (20.8%) | 13 (24.1%) | - |
| Total | 85 | 202.8 ± 123.3 | 2.0 ± 1.3 | 15 (17.6%) | 53 (61.4%) | 14 (16.5%) | 17 (20.0%) | - |
* Significant difference between two areas determined by Independent t test (p < 0.001)
** Significant difference between two areas determined by Chi square test (p < 0.001)