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Characterization of the four QN-resistant isolates of Plasmodium falciparum
| SK20 | SK22 | MR2 | KB12 | |
|---|---|---|---|---|
| Origin | Srisaket | Srisaket | Chantaburi | Kanchanaburi |
| QN IC50 (nM) | 521.8 | 503.0 | 530.6 | 654.4 |
| Pfmdr1 mutations | ||||
| N86Y | N | N | N | N |
| Y184F | F | F | F | F |
| S1034C | S | S | S | C |
| N1042D | N | N | N | D |
| D1246Y | D | D | D | D |
| Pfmdr1 copy number | 0.8 | 0.9 | 1.2 | 2.0 |
| Pfnhe-1 | ||||
| DNNND repeats | 3 | 4 | 1 | 3 |
| DDNNNDNHNDD repeats | 1 | 2 | 1 | 1 |
| NHNDNHNNDDD repeats | 1 | 1 | 0 | 1 |
